a day; occasionally, doses up to 320 mg a day may be needed. Effects of beta blockade. Effectiveness of low-dose nadolol for ventricular arrhythmias. Appropriate laboratory testing is recommended at the first sign and/or symptom of hepatotoxicity; if there is laboratory evidence of hepatotoxicity, it is recommended that labetalol be permanently withdrawn. 159 Note: To maintain satisfactory blood pressure control, some patients may require division of the total daily dose into three separate doses. Dumon JP, Catteau J, Lanvin F, Dupuis.
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Morganroth J, Duchin. Propranolol package insert (Inderal, WyethUS Rev 4/92, Rec 2/93. Lack of efficacy of d-propranolol in neuroleptic-induced akathisia. 159 A repeat of the 21-month study in mice found no increased incidence of any type of tumor. Labetalol injection package insert (Normodyne, ScheringUS Rev 4/90, Rec 5/92. Labetalol Beta-1; Beta-2 100 Moderate (50) Hepatic 68 (oral.5 (IV) 24 (oral 5 min (IV) 5560 ( 5) Renal; Biliary/fecal No Metoprolol Beta-1 * 95 Low (12) Hepatic 37 12 (oral regular 612 (oral long-acting 20 min (IV) Renal (310) No Nadolol Beta-1; Beta-2. 42 Oxprenolol Long-term studies in mice and rats found no evidence of carcinogenicity. Clin Pharmacol Ther 1989; 46: 56-62. Recognition and management of cardiovascular disease related to thyroid dysfunction.